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abl Proto Oncogene Proteins

《英文msh詞典》abl Proto Oncogene Proteins
[入口詞] abl Proto Oncogene Proteins
[主題詞] Proto-Oncogene Proteins c-abl
[英文釋義] Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted,releasing the kinase from negative regulation.

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